BEESEN BIO R&D
Refined natural substance that removes harmful ingredients from bee venom with new substances
It is a model of ancient Greek neoplatonism, which is believed to reproduce the same pattern at every stage of the universe. In this system, the center is human of the universe.
M4A developed from bee stings as a medicine
Innovative research of Yuma Heal Bio, which opens a new paradigm for new drug development, continues.
The Yuma Heal - Beesen Bio R&D Center has research capabilities and technologies accumulated throughout the bio industry.
We are striving to develop high-quality medicines and new products through intensive R&D investment and securing excellent research manpower such as master's and doctoral degrees.
In addition to developing new drugs, we are expanding the scope of application to bio products that improve the quality of life, such as anti-aging cosmetic raw materials and health functional foods, and we are making bold investments in R&D for sustainable growth.
Yuma Heal - Beesen Bio's efforts for healthy and prosperous lives for all people around the world will continue, and we are doing our best today to develop and produce the world's best quality medicines.
Patented substance "M4A"
"M4A"_Refined Natural Substances
M4A is a new material researched and developed by our company, and it is a refined natural material that has removed harmful components from bee venom. Yuma Heal-Bisen Bio is concentrating its research capabilities on natural medicines derived from bee venom as its main item. Bee venom-related separation/purification technology is Bisen Bio's core competitiveness and based on this, we are conducting research in various fields such as anti-atopic, anti-diabetic, anti-aging, and developing source materials. In addition, the technology used in the development of M4A is applied to many natural products other than bee venom, and various natural product bio research is being conducted.
Antioxidant M4A, the golden key to overcoming incurable diseases
• Anti-inflammatory + Antibacterial + Antiviral
• Eliminate / Reduce Inflammation
• Remove / Reduce mold, Bacteria and Germs
• Immune function regulation
• Anti-Aging Effect
M4A is a high-purity special safe bee venom made by recombining active ingredients suitable for each disease in a special ratio through removal of allergens from natural bee venom and separation of ingredients after purification, and amplifying ingredients that are helpful in treatment. The effectiveness of M4A has been confirmed for the treatment of intractable diseases such as anti-aging, diabetes, atopy, and psoriasis, and the number of clinical cases is continuously increasing.
Core technology
Separation and purification technology of bee venom (reblending)
In order to use M4A developed from bee stinger as pharmaceuticals (diabetes, arthritis, gout, Parkinson's, dementia, cancer, etc.), it is necessary to separate and purify the components of pure bee venom and then re-blend them. The technology of the process of removing and refining impurities and allergens from bee venom is a differentiated core technology of Bissen, and researchers with various research spectrums strive for technology concentration and upgrade to develop raw materials suitable for causal treatment of various diseases. are racing.
Patented substance "M4A-ATP"
M4A-ATP (Atopic Treatment)
M4A-ATP is a natural medicine developed as a treatment for severe skin diseases such as atopic dermatitis, psoriasis, and seborrheic dermatitis based on the strong anti-inflammatory and antibacterial effects of M4A.
Our Lab. strengthens the detoxification function (antioxidant, anti-inflammatory, anti-toxin function) through blood, liver and kidney as well as skin. We have developed M4A-ATP that can fundamentally treat atopy by restoring the normal immune function of the intestine and preventing intestinal leakage.
Atopic dermatitis treatment program
• Detoxification
• Immune boost
• Skin care
• Spa (SPA)
Atopy is a representative autoimmune disease that invades the whole body. It is an incurable disease for which there is no proper treatment yet, and it is a very serious immune system disease in that it greatly affects the quality of life of the patient.
M4A-ATP has anti-inflammatory effects and It restores the normal function of the intestine, which is responsible for more than 80% of the immune function.
By operating a CTP (Customized Therapy Program) according to the patient's condition, such as oral preparations, ointments, sprays, and spas, the fundamental treatment effect of atopic dermatitis is expected.
Currently, intensive treatment is being carried out at the M4A Atopic Center of a designated hospital.
Patented substance "M4A-D1"
M4A-D1 (Diabetes Treatment)
As a result of the 'diabetic preclinical study on pancreatic cell regeneration', it was confirmed that the blood sugar control effect was excellent and the function of pancreatic beta cells was activated.
As a result of the "Study on the treatment effect of type 1 diabetes (insulin-dependent diabetes) using bee venom from bee venom" jointly with Chungbuk National University, it was confirmed that the function of pancreatic beta cells was activated, and the results of the study were reported in the SCI International Medical Journal. , presented at the 2018 London Diabetes Association (presenter: Professor Jae-Kwon Lee, Chungbuk National University) and became a hot topic.
Treatment effect of type 1 diabetes (insulin-dependent diabetes) using bee venom as a raw material
• Blood sugar control
• Regeneration of pancreatic beta cells
• Restoration of liver function levels to normal
Diabetes mellitus is caused by damage to the pancreatic beta cells that secrete insulin or a decrease in the insulin recognition rate of living cells. M4A-D1 enables fundamental treatment by inhibiting or restoring the damage and deterioration of pancreatic cells. Animal experiments on type 2 diabetes are currently in progress, and statistically significant (significant) efficacy is confirmed.
Diabetes is accompanied by various complications, and since most of them are inflammatory diseases, if bee venom, which has anti-inflammatory or immune enhancement or blood-cleaning effects, is applied as a treatment, it is expected to have a great effect on not only diabetes but also complications caused by it.
CONCLUSION
We conclusively affirm that BWV formulation exerted anti-diabetic property over bee venom alone which might achieve through controlled relaxation of bee venom by bee wax.
The secondary metabolites in bee venom such as melittin and PLA2 present in BWV formulation reduced the β-cell damage leads to β-cell regeneration which resulted in increased insulin level.
At the same time, enhanced insulin secretion in diabetic rats through potassium channel closer and calcium channel opening.
Furthermore, BWV formulation increased insulin signaling by downregulation of PI3K-p85 subunit, a dominant signaling pathway gene, and up-regulated the hepatic GCK leads to normalizing glucose hemostasis.
Moreover, octacosanol, octadecanoic, triacontanol present in BWV formulation modulated the altered cholesterol metabolism and reduced the toxic hepatic biomarkers such as SGOT, and SGPT shows BWV formulation has no toxic effect. These results suggest that BWV formulation can be considered as a drug for the treatment of diabetes mellitus.
Patented substance "M4A-Spa"
M4A-SPA (Spa Therapy)
It is a medical spa that treats skin diseases and activates physiological functions through the combined action of M4A and high-purity mineral water.
M4A-SPA is a medical spa that combines the powerful anti-inflammatory, antibacterial and antiviral effects of M4A with the treatment of skin diseases such as atopic dermatitis, immunity enhancement, active metabolism, and skin beauty treatment with mineral water and pearl powder. in pursuit of health.
A system for skin disease treatment and physiological activation installed in the bathroom
• M4A : Clean blood + blood circulation improvement
• Pearl powder: high-purity complex mineral physiological action and highly active
• 40℃ hold for 30 minutes
The first purpose of the spa is to treat skin diseases with the combined action of M4A, mineral water and pearl powder.
In addition, it improves immunity by promoting blood and lymph circulation and metabolism.
It helps to open the pores of the skin to discharge waste products and remove old keratinocytes to make the skin softer and more supple.
In addition, management using warm water lowers the tension of the muscles of the human body.
It has an excellent effect on muscle relaxation by softening the joints, and you can expect a balanced body shape along with anti-aging, stress relief, detoxification, and slimming.
Patented substance "Shell X"
Shell X
Acquisition of technology to peel off the hard protein shell "exin" of pollen
Several companies have tried to peel the pollen husk axin, but it has been difficult to artificially break it.
However, Yuma Heal - BisenBio has developed a technology that helps the absorption of various nutrients contained in the existing pollen and enhances its effectiveness.
BEE POLLEN secondary separation technology "Shell X"
Bee Pollen 100 Million Years of Nutrient Crystals
Boost immunity
Enhanced physiological activation
Antibacterial
Antiviral
Antioxidant, anticancer, antibacterial
Female menopause
Menopause improvement
Male stamina
Anti-cancer,
Cancer cell death, tumor suppression/blocking
Eliminate inflammation
Liver protection and strengthening
Heart Ginger LDL Cholesterol
Mast cells
Diet
Sleep extension
Corona 19 and the second and third virus solutions and preventive measures "increase immunity"
Acta Derm Venereol
2012; 92: 16–23
Acta Derm Venereol
2012; 92: 16–23
Core Values
Patent Natural Substances
"M4A"
• Anti-inflammatory + antibacterial + antiviral
• Eliminate/reduce inflammation
• Remove/reduce mold, bacteria and germs
• Immune function regulation• Anti-aging
effect
M4A-ATP
• Detoxification• Immune boost
• Skin care
• Spa (SPA)
M4A-D1
• Blood sugar control
• Regeneration of pancreatic beta cells
• Restoration of liver function levels to normal
M4A-SPA
• Clean blood + blood circulation improvement
• Pearl powder: high-purity complex mineral
physiological action and highly active
• 40℃ hold for 30 minutes
"Shell X"
Shell X, Bio-Technology
The world's first secondary industrialization technology that includes a series of industrialization processes and bio-processing processes that separate the pollen husks, absorb maximum nutrients into the body, and dramatically increase storage stability and convenience.
Characteristic Shell X
100% absorbed by the body
Extended retention period (up to 2 years)
Nullification of pollen allergy
Neutralize heavy metal contamination
Separation of 250 bioactive substances